Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358230 | 0.85 | ALDH1A1 (0.49) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL5935764 | 0.85 | ALDH1A1 (0.49) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL8057921 | 0.83 | — | — | |
| SCHEMBL6733610 | 0.83 | TAAR1 (0.50) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL10689465 | 0.82 | LMNA (0.46) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL12064579 | 0.82 | TAAR1 (0.48) | ALDH1A1TSHRMAPTHTTTAAR1 | |
| SCHEMBL19100212 | 0.81 | LMNA (0.45) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL8055385 | 0.80 | ALDH1A1 (0.43) | MAPK1ALDH1A1TSHRGAAKDM4E | |
| SCHEMBL8905908 | 0.80 | SLC1A3 (0.42) | MAPK1DPP4ALDH1A1TSHRGAA | |
| SCHEMBL15700931 | 0.79 | SMN1; SMN2 (0.42) | MAPK1DPP4ALDH1A1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |