Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.40 |
| ▸ | RAB9A | P51151 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767260 | 0.73 | PTGS1 (0.37) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4150903 | 0.72 | CYP2C9 (0.40) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7451095 | 0.71 | SMPD3 (0.40) | ADORA2AADORA1 | |
| SCHEMBL7453983 | 0.70 | RPS6KB2 (0.41) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL7112445 | 0.69 | CLK4 (0.36) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL9769080 | 0.69 | ALDH1A1 (0.50) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL7105969 | 0.68 | NPC1 (0.40) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL3220235 | 0.67 | RAB9A (0.39) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL7455270 | 0.64 | KDM4E (0.40) | NPC1RAB9AKDM4EPKMMAPT | |
| SCHEMBL19127576 | 0.63 | ERN1 (0.40) | NPC1RAB9AKDM4EPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |