Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.63 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430092 | 0.84 | SCN9A (0.61) | SCN9ATLR8KMOKDM4EMEN1 | |
| SCHEMBL12907953 | 0.82 | SCN9A (0.61) | SCN9ATLR8KDM4EMEN1MAPT | |
| SCHEMBL7433050 | 0.79 | SCN9A (0.43) | SCN9AHPGDSF2RL3TLR8KMO | |
| SCHEMBL7440302 | 0.77 | SCN9A (0.53) | SCN9ATLR8KDM4EMEN1MAPT | |
| SCHEMBL7433045 | 0.76 | SCN9A (0.40) | SCN9AHPGDSF2RL3TLR8KMO | |
| SCHEMBL3670564 | 0.75 | SCN9A (0.51) | SCN9AF2RL3TLR8KDM4EMEN1 | |
| SCHEMBL1385874 | 0.74 | SCN4A (0.58) | SCN9A | |
| SCHEMBL20017684 | 0.74 | PDE10A (0.54) | F2RL3TLR8KDM4EMEN1MAPT | |
| SCHEMBL259657 | 0.71 | PDE10A (0.54) | F2RL3TLR8KDM4EMEN1MAPT | |
| SCHEMBL7431062 | 0.71 | KMO (0.52) | SCN9ATLR8KMOKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |