Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670564 | 0.83 | SCN9A (0.51) | SCN9AALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7430092 | 0.81 | SCN9A (0.61) | SCN9AALDH1A1MAPTTLR8NPC1 | |
| SCHEMBL12907953 | 0.78 | SCN9A (0.61) | SCN9AALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL29504931 | 0.78 | SCN9A (0.49) | SCN9ABRD4MAPTCA9NPC1 | |
| SCHEMBL7432591 | 0.78 | ALDH1A1 (0.37) | SCN9AALDH1A1BRD4BRD9MAPT | |
| SCHEMBL7444775 | 0.77 | SCN9A (0.63) | SCN9AMAPTTLR8KDM4EMEN1 | |
| SCHEMBL30098806 | 0.77 | CASP3 (0.50) | SCN9AALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7432583 | 0.75 | ALDH1A1 (0.34) | SCN9AALDH1A1BRD4MAPTSMN1; SMN2 | |
| SCHEMBL5306596 | 0.74 | MAPT (0.42) | ALDH1A1BRD4BRD9MAPTSMN1; SMN2 | |
| SCHEMBL30098723 | 0.73 | SCN9A (0.56) | SCN9AALDH1A1MAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |