Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 10/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442930 | 0.87 | DRD3 (0.54) | SLC6A4KCNH2DRD3CCR5 | |
| SCHEMBL7439267 | 0.83 | FYN (0.41) | DRD3DRD2 | |
| SCHEMBL7442254 | 0.81 | ALDH1A1 (0.46) | SLC6A4KCNH2CCR5 | |
| SCHEMBL7445531 | 0.80 | SLC6A4 (0.41) | SLC6A4KCNH2DRD3DRD2 | |
| SCHEMBL1544812 | 0.78 | NR1H2 (0.42) | DRD3DRD2 | |
| SCHEMBL1544809 | 0.78 | NR1H2 (0.42) | DRD3DRD2 | |
| SCHEMBL1545069 | 0.78 | NR1H2 (0.42) | DRD3DRD2 | |
| SCHEMBL13434159 | 0.77 | SLC6A4 (0.58) | SLC6A4KCNH2CCR5 | |
| SCHEMBL13911241 | 0.76 | SLC6A4 (0.56) | SLC6A4KCNH2CCR5 | |
| SCHEMBL7861296 | 0.74 | DRD3 (0.64) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |