Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 3/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442930 | 0.86 | DRD3 (0.54) | SLC6A4KCNH2DRD3HTR1A | |
| SCHEMBL7443025 | 0.84 | DRD3 (0.42) | DRD3HTR1AHTR7DRD2DRD4 | |
| SCHEMBL7447925 | 0.82 | ALDH1A1 (0.40) | SLC6A4KCNH2DRD3HTR1AHTR7 | |
| SCHEMBL7444816 | 0.80 | SLC6A4 (0.44) | SLC6A4KCNH2DRD3DRD2 | |
| SCHEMBL7437479 | 0.76 | DRD3 (0.65) | DRD3HTR1AHTR7DRD2DRD4 | |
| SCHEMBL13434159 | 0.76 | SLC6A4 (0.58) | SLC6A4KCNH2 | |
| SCHEMBL13911241 | 0.75 | SLC6A4 (0.56) | SLC6A4KCNH2 | |
| SCHEMBL7335068 | 0.74 | DRD2 (0.51) | DRD3HTR1AHTR7DRD2DRD4 | |
| SCHEMBL13911269 | 0.72 | AGER (0.56) | SLC6A4KCNH2 | |
| SCHEMBL7442254 | 0.71 | ALDH1A1 (0.46) | SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |