Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.50 |
| ▸ | CCR8 | P51685 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30563009 | 0.88 | CCR1 (0.52) | BRD4SERPINE1MAPTCCR1CCR8 | |
| SCHEMBL27191397 | 0.88 | CCR1 (0.52) | BRD4SERPINE1MAPTCCR1CCR8 | |
| SCHEMBL7440046 | 0.83 | PDE4A (0.54) | DHFRPDE4DPDE4APDE4CCCR1 | |
| SCHEMBL16581166 | 0.82 | MMP2 (0.54) | BRD4SERPINE1MAPTCCR1CCR8 | |
| SCHEMBL31617682 | 0.82 | MAP4K4 (0.52) | PDE4DPDE4APDE4CMAPTCCR1 | |
| SCHEMBL17334526 | 0.81 | CCR1 (0.62) | BRD4MAPTCCR1CCR8KDM4E | |
| SCHEMBL19036144 | 0.81 | BRD4 (0.45) | BRD4SERPINE1PDE4DPDE4APDE4C | |
| SCHEMBL31617744 | 0.80 | MAP4K4 (0.50) | BRD4PDE4DPDE4APDE4CMAPT | |
| SCHEMBL4148271 | 0.80 | MMP2 (0.60) | BRD4PDE4AMAPTCCR1CCR8 | |
| SCHEMBL7450702 | 0.79 | PDE4A (0.60) | DHFRPDE4DPDE4APDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |