Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437414 | 0.96 | MAPT (0.56) | MAPTTDP1POLBROCK2HCRTR1 | |
| SCHEMBL20250626 | 0.81 | CTSL (0.64) | MAPTTDP1POLBROCK2 | |
| SCHEMBL28766228 | 0.81 | CTSL (0.64) | MAPTTDP1POLBROCK2 | |
| SCHEMBL7436414 | 0.80 | MAPT (0.61) | MAPTTDP1POLBHCRTR1NPSR1 | |
| SCHEMBL7427177 | 0.80 | MAPT (0.64) | MAPTTDP1POLBHCRTR1NPSR1 | |
| SCHEMBL15630652 | 0.76 | MAPT (0.60) | MAPTTDP1POLBNPSR1ATM | |
| SCHEMBL16459753 | 0.76 | CTSS (0.68) | MAPTTDP1POLBATMMEN1 | |
| SCHEMBL13645698 | 0.76 | MAPT (0.60) | MAPTTDP1POLBNPSR1ATM | |
| SCHEMBL18435382 | 0.76 | CTSS (0.68) | MAPTTDP1POLBATMMEN1 | |
| SCHEMBL16459752 | 0.76 | CTSS (0.68) | MAPTTDP1POLBATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0364493-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1990-04-25 | — | — | EP | claimed |
| WO-1989001488-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1989-02-23 | — | — | WO | claimed |
| EP-0364493-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1989001488-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1989-02-23 | — | — | WO | disclosed |