Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.61 |
| ▸ | FPR2 | P25090 | 3/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441718 | 0.88 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL4940189 | 0.85 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL5823060 | 0.83 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7696540 | 0.82 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL1157568 | 0.81 | POLB (0.51) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8203884 | 0.81 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL6798284 | 0.80 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL8206942 | 0.79 | PDE5A (0.57) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL1714036 | 0.79 | PDE4A (0.42) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7434745 | 0.77 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | claimed |
| EP-0745063-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-04 | — | — | EP | claimed |
| WO-1995022520-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-08-24 | — | — | WO | claimed |
| US-6080790-A | SELECTIVE AND POTENT INHIBITORS OF PHOSPHODIESTERASE IV AND ARE USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY DISEASES AND THE ALLEVIATION OF CONDITIONS ASSOCIATED WITH CENTRAL NERVOUS MALFUNCTION | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0618889-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1998-12-30 | — | — | EP | disclosed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| US-5674880-A | ANTIINFLAMMATORY AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| US-5650444-A | BRONCHODILATOR AGENTS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-07-22 | — | — | US | disclosed |
| US-5491147-A | PHOSPHODIESTERASE IV INHIBITORS | CELLTECH, LIMITED (GB) | 1996-02-13 | — | — | US | disclosed |