Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 8/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370758 | 0.86 | — | — | |
| SCHEMBL8483493 | 0.85 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8204723 | 0.82 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8478447 | 0.81 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5823060 | 0.79 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7441718 | 0.79 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8209553 | 0.79 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7445077 | 0.79 | PDE4A (0.61) | PDE5APDE1APDE1BPDE1CPDE4A | |
| SCHEMBL7696540 | 0.78 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL9701913 | 0.78 | KDM4E (0.53) | PDE5APDE1APDE1BPDE1CPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080790-A | SELECTIVE AND POTENT INHIBITORS OF PHOSPHODIESTERASE IV AND ARE USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY DISEASES AND THE ALLEVIATION OF CONDITIONS ASSOCIATED WITH CENTRAL NERVOUS MALFUNCTION | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0618889-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1998-12-30 | — | — | EP | disclosed |
| US-5674880-A | ANTIINFLAMMATORY AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| US-5491147-A | PHOSPHODIESTERASE IV INHIBITORS | CELLTECH, LIMITED (GB) | 1996-02-13 | — | — | US | disclosed |