SCHEMBL7445171

SCHEMBL7445171

COC(=O)c1cc(OC)c(CN2CCCC2)c(OC)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
CASP1 P29466 1/20 0.50
HSD17B10 Q99714 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
POLB P06746 1/20 0.49
SMN1; SMN2 Q16637 6/20 0.48
GAA P10253 1/20 0.48
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
MEN1 O00255 2/20 0.47
LMNA P02545 2/20 0.47
KMT2A Q03164 2/20 0.47
CYP1A2 P05177 1/20 0.47
HTT P42858 1/20 0.47
ABCC4 O15439 1/20 0.47
CYP3A4 P08684 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3209262 0.94 SLC29A1 (0.51) KDM4EALDH1A1HPGDALOX15CASP1
SCHEMBL13427885 0.86 DDR1 (0.48) KDM4EALDH1A1HPGDALOX15CASP1
Hydrochloric Acid SCHEMBL7445424 0.85 POLB (0.52) L3MBTL1POLBSMN1; SMN2GAACYP2D6
Bromide SCHEMBL3217532 0.85 DDR1 (0.47) KDM4EALDH1A1HPGDALOX15CASP1
SCHEMBL2624494 0.81 L3MBTL1 (0.59) KDM4EALDH1A1HPGDALOX15CASP1
SCHEMBL3220718 0.81 ALDH1A1 (0.41) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL3229628 0.80 CA12 (0.53) KDM4EALDH1A1HPGDHSD17B10POLB
SCHEMBL11796998 0.78 POLB (0.55) KDM4EALDH1A1POLBSMN1; SMN2GAA
SCHEMBL20196200 0.78 ALDH1A1 (0.47) KDM4EALDH1A1HPGDL3MBTL1POLB
SCHEMBL1427541 0.78 GAA (0.61) KDM4EALDH1A1L3MBTL1POLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265575-B1 THROMBIN INHIBITORS ELI LILLY AND COMPANY 2001-07-24 US disclosed
US-6251921-B1 ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL ELI LILLY AND COMPANY 2001-06-26 US disclosed
US-6025382-A Antithrombotic diamines ELI LILLY AND COMPANY (US) 2000-02-15 US disclosed
EP-0863755-A4 ANTITHROMBOTIC DIAMINES LILLY CO ELI (US) 1999-01-20 EP disclosed
EP-0863755-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1998-09-16 EP disclosed
WO-1997025033-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1997-07-17 WO disclosed