Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052781 | 0.81 | LMNA (0.45) | LMNACYP2C19L3MBTL1FDPSTHRB | |
| SCHEMBL8049538 | 0.77 | LMNA (0.35) | LMNACYP2C19 | |
| SCHEMBL5897536 | 0.75 | LMNA (0.60) | LMNACYP2C19FDPS | |
| SCHEMBL4763235 | 0.73 | CYP2C19 (0.31) | LMNACYP2C19 | |
| SCHEMBL8674990 | 0.73 | LMNA (0.32) | LMNACYP2C19L3MBTL1 | |
| SCHEMBL8049770 | 0.73 | LMNA (0.43) | LMNAFDPS | |
| SCHEMBL10787528 | 0.71 | LMNA (0.41) | LMNACYP2C19FDPS | |
| SCHEMBL8038111 | 0.69 | LMNA (0.35) | LMNA | |
| SCHEMBL5665801 | 0.69 | L3MBTL1 (0.32) | LMNACYP2C19L3MBTL1 | |
| SCHEMBL18628658 | 0.69 | LMNA (0.30) | LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686434-A | PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0730587-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014680-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0054715-A2 | Esters of propanoic acid, preparation of these compounds, weed killers containing these compounds as active ingredients, use of such compounds and compositions for the control of weeds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-30 | — | — | EP | disclosed |
| US-4022757-A | Dicarbamic acid diesters containing phosphorus | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-10 | — | — | US | disclosed |