Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422522 | 0.88 | MAPK14 (0.59) | MAPK14CSNK1DPTGER1ALOX5MAPK13 | |
| SCHEMBL5079652 | 0.88 | MAPK14 (0.59) | MAPK14CSNK1DPTGER1ALOX5MAPK13 | |
| SCHEMBL4426392 | 0.83 | MAPK14 (0.52) | MAPK14CSNK1DPTGER1FABP4FABP5 | |
| SCHEMBL8488765 | 0.79 | MAPK14 (0.55) | MAPK14CSNK1DPTGER1FABP4FABP5 | |
| SCHEMBL7228732 | 0.79 | RAF1 (0.57) | MAPK14CSNK1DPTGER1ALOX5MAPK13 | |
| SCHEMBL4426390 | 0.79 | RAF1 (0.57) | MAPK14CSNK1DPTGER1ALOX5MAPK13 | |
| SCHEMBL27372589 | 0.78 | MAPK14 (0.49) | MAPK14CSNK1DPTGER1FABP4FABP5 | |
| SCHEMBL20271796 | 0.77 | FABP4 (0.51) | MAPK14CSNK1DPTGER1FABP4FABP5 | |
| SCHEMBL1808538 | 0.76 | HDAC1 (0.57) | — | |
| SCHEMBL5082516 | 0.75 | MAPK14 (0.53) | MAPK14CSNK1DPTGER1FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623126-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014081-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-07-22 | — | — | WO | disclosed |