Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437020 | 0.84 | HPGD (0.50) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7435440 | 0.82 | HPGD (0.57) | ALDH1A1NPSR1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7447211 | 0.80 | HPGD (0.44) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7430972 | 0.76 | KDM4E (0.53) | ALOX15HSD17B10HTTMAPTTLR7 | |
| SCHEMBL7441201 | 0.74 | HSD17B10 (0.46) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7435426 | 0.74 | HSD17B10 (0.44) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7441205 | 0.74 | HSD17B10 (0.46) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7435432 | 0.74 | HSD17B10 (0.44) | ALOX15HSD17B10ALDH1A1NPSR1HTT | |
| SCHEMBL7439781 | 0.74 | GAA (0.60) | ALDH1A1HTTHPGDSMN1; SMN2LMNA | |
| SCHEMBL15691477 | 0.72 | PDE2A (0.50) | HSD17B10ALDH1A1NPSR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |