Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437020 | 0.87 | HPGD (0.50) | HPGDALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL15691477 | 0.85 | PDE2A (0.50) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7445337 | 0.82 | ALOX15 (0.47) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7447211 | 0.80 | HPGD (0.44) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7441558 | 0.76 | KDM4E (0.56) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL1723787 | 0.76 | TLR7 (0.46) | BRD4 | |
| SCHEMBL7449928 | 0.74 | TSHR (0.46) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7449932 | 0.74 | TSHR (0.46) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7446937 | 0.74 | TSHR (0.44) | HPGDALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL7446930 | 0.74 | TSHR (0.44) | HPGDALDH1A1LMNASMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |