Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TPH1 | P17752 | 1/20 | 0.46 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176299 | 0.85 | KDM4E (0.65) | KDM4EHPGDBRAFKMT2AMEN1 | |
| SCHEMBL556003 | 0.85 | KDM4E (0.55) | KDM4EHPGDBRAFKMT2AMEN1 | |
| SCHEMBL7441558 | 0.82 | KDM4E (0.56) | KDM4EHPGDBRAFKMT2AMEN1 | |
| SCHEMBL7434786 | 0.81 | HPGD (0.51) | KDM4EHPGDBRAFKMT2AMEN1 | |
| SCHEMBL9707844 | 0.80 | AGTR1 (0.45) | GPR18 | |
| SCHEMBL28749924 | 0.78 | TSHR (0.50) | KDM4EHPGDKMT2AMEN1ALOX15 | |
| SCHEMBL3228294 | 0.77 | ATM (0.46) | HPGDBRAFKMT2AMEN1LMNA | |
| SCHEMBL7445337 | 0.76 | ALOX15 (0.47) | KDM4EHPGDALOX15HSD17B10LMNA | |
| SCHEMBL5867203 | 0.75 | TSHR (0.48) | HPGDKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL10830749 | 0.75 | HPGD (0.43) | KDM4EHPGDBRAFKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |