Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448803 | 0.89 | ALDH1A1 (0.55) | ABCG2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL10427732 | 0.80 | NAPRT (0.51) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL11366517 | 0.80 | GRM4 (0.53) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL12048735 | 0.74 | ABCG2 (0.59) | ABCG2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2181678 | 0.73 | MEN1 (0.50) | ABCG2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL7273341 | 0.73 | PDE4D (0.60) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL10768030 | 0.73 | PDE4D (0.60) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL12550512 | 0.72 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL28694564 | 0.72 | NAPRT (0.46) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL8804915 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPTKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |