Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445370 | 0.89 | ABCG2 (0.51) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL3714860 | 0.78 | KCNA5 (0.49) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27993567 | 0.74 | KMT2A (0.60) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL2181678 | 0.72 | MEN1 (0.50) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL2728969 | 0.72 | EGFR (0.47) | ALDH1A1KMT2ANPC1RAB9ATSHR | |
| SCHEMBL12550512 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL2770958 | 0.71 | PARP1 (0.51) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL5249571 | 0.71 | MAPT (1.00) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL8804915 | 0.71 | ALDH1A1 (0.50) | ALDH1A1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL12048735 | 0.70 | ABCG2 (0.59) | ALDH1A1KMT2AMAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |