Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.58 |
| ▸ | ACE | P12821 | 6/20 | 0.58 |
| ▸ | CPA1 | P15085 | 3/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444227 | 0.80 | ITGB1 (0.55) | CA2ITGB1ITGA4ADAMTS5MMP2 | |
| SCHEMBL7447944 | 0.78 | MME (0.52) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7442952 | 0.78 | ITGB1 (0.53) | ACECA2ITGB1ITGA4ADAMTS5 | |
| SCHEMBL7360349 | 0.77 | MMP2 (0.72) | ITGB1ITGA4ADAMTS5MMP2MMP9 | |
| SCHEMBL7381453 | 0.77 | MMP2 (0.72) | ITGB1ITGA4ADAMTS5MMP2MMP9 | |
| SCHEMBL7448892 | 0.76 | MMP2 (0.53) | ACECA2ITGB1ITGA4ADAMTS5 | |
| SCHEMBL15342313 | 0.76 | MME (0.60) | MMEACECPA1ACE2CA2 | |
| SCHEMBL29386041 | 0.76 | MME (0.60) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7298796 | 0.76 | MMP2 (0.70) | ADAMTS5MMP2MMP9POLBF2 | |
| SCHEMBL31296488 | 0.75 | MME (0.71) | MMEACECPA1ACE2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |