Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 7/20 | 0.52 |
| ▸ | ACE | P12821 | 6/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452231 | 0.86 | MME (0.50) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7448688 | 0.86 | ITGB1 (0.48) | MMEACECPA1ACE2ITGA4 | |
| SCHEMBL7447863 | 0.85 | MME (0.51) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7514233 | 0.84 | MME (0.49) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7445482 | 0.78 | MME (0.58) | MMEACECPA1ACE2ITGA4 | |
| SCHEMBL7447456 | 0.77 | MME (0.56) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7449822 | 0.73 | ITGA4 (0.48) | ITGA4ITGB1ADAMTS4MMP9MMP8 | |
| SCHEMBL30416156 | 0.73 | MME (0.70) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7971237 | 0.72 | ADAMTS4 (0.58) | ITGA4CA2ITGB1ADAMTS4MMP9 | |
| SCHEMBL29386041 | 0.72 | MME (0.60) | MMEACECPA1ACE2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221888-B1 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENT, AUTOIMMUNE DISEASE, RHEUMATIC DISORDERS | MERCK & CO., INC. | 2001-04-24 | — | — | US | claimed |
| EP-0998282-A4 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2000-08-30 | — | — | EP | claimed |
| EP-0998282-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998053818-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | claimed |