Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19097411 | 0.93 | ESR2 (0.41) | TLR9TLR8TLR7ESR2 | |
| SCHEMBL8193235 | 0.93 | ESR2 (0.41) | TLR9TLR8TLR7ESR2 | |
| SCHEMBL6042043 | 0.93 | ESR2 (0.41) | TLR9TLR8TLR7ESR2 | |
| Hydrochloric Acid SCHEMBL4601092 | 0.92 | GRK2 (0.41) | TLR9TLR8TLR7ESR2 | |
| Bicarbonate SCHEMBL7443967 | 0.87 | MAPT (0.49) | JAK3MAPTPKMFPR1FPR2 | |
| SCHEMBL8317532 | 0.81 | KDM1A (0.50) | MAPTPKMFPR1FPR2 | |
| SCHEMBL11565322 | 0.81 | KDM1A (0.50) | MAPTPKMFPR1FPR2 | |
| SCHEMBL407883 | 0.81 | KDM1A (0.50) | MAPTPKMFPR1FPR2 | |
| SCHEMBL8471748 | 0.81 | KDM1A (0.50) | MAPTPKMFPR1FPR2 | |
| SCHEMBL8870050 | 0.81 | KDM1A (0.50) | MAPTPKMFPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |