Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454489 | 1.00 | NPC1 (0.38) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7447136 | 0.93 | ALDH1A1 (0.37) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7447505 | 0.92 | NPC1 (0.36) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7442305 | 0.88 | F2 (0.48) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| Hydrochloric Acid SCHEMBL7449029 | 0.87 | F2 (0.47) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| Hydrochloric Acid SCHEMBL7418107 | 0.87 | F2 (0.47) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7453448 | 0.87 | RAB9A (0.41) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7449129 | 0.86 | RAB9A (0.40) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7421109 | 0.85 | NPC1 (0.37) | NPC1ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL7442673 | 0.85 | MLLT1 (0.34) | NPC1ALDH1A1RAB9ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |