Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 11/20 | 0.72 |
| ▸ | TPSD1 | Q9BZJ3 | 11/20 | 0.72 |
| ▸ | TPSG1 | Q9NRR2 | 11/20 | 0.72 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.52 |
| ▸ | F2 | P00734 | 3/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.45 |
| ▸ | F2R | P25116 | 7/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446694 | 0.87 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7446751 | 0.81 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL8396720 | 0.80 | TPSAB1 (0.52) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8392284 | 0.79 | TPSAB1 (0.55) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8394481 | 0.79 | EPHX1 (0.53) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8391573 | 0.79 | EPHX1 (0.53) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8396002 | 0.79 | EPHX1 (0.53) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8391395 | 0.79 | EPHX1 (0.53) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8395303 | 0.79 | EPHX1 (0.53) | TPSAB1TPSD1TPSG1SIGMAR1 | |
| SCHEMBL8396537 | 0.79 | TPSAB1 (0.54) | TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |