Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.49 |
| ▸ | HTR2B | P41595 | 8/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11034439 | 0.80 | HTR2C (0.49) | HTR2CHTR2BTAAR1HTR2AMAOB | |
| SCHEMBL27600521 | 0.77 | SLC6A2 (0.44) | HTR2CHTR2BTAAR1HTR2A | |
| SCHEMBL669693 | 0.77 | HTR2C (0.50) | HTR2CHTR2BTAAR1HTR2AGAA | |
| SCHEMBL4432187 | 0.76 | HTR2C (0.46) | HTR2CHTR2BTAAR1HTR2AKDM1A | |
| SCHEMBL8588169 | 0.76 | HTR2C (0.46) | HTR2CHTR2BTAAR1HTR2AKDM1A | |
| SCHEMBL5915114 | 0.74 | HTR2C (0.44) | HTR2CHTR2BTAAR1HTR2AMAOB | |
| SCHEMBL8570450 | 0.74 | SIGMAR1 (0.45) | HTR2CHTR2BTAAR1HTR2AKDM4E | |
| SCHEMBL28532920 | 0.72 | HTR2C (0.40) | HTR2CHTR2BTAAR1HTR2AMAOB | |
| SCHEMBL8223310 | 0.72 | TAAR1 (0.43) | HTR2CHTR2BTAAR1HTR2AMAOB | |
| SCHEMBL1947262 | 0.72 | HTR2C (0.48) | HTR2CHTR2BTAAR1HTR2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131306-A2 | ISOXAZOLINE FIBRINOGEN RECEPTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029406-A2 | NOVEL ISOXAZOLINE FIBRINOGEN RECEPTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-05-25 | — | — | WO | disclosed |