Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433481 | 1.00 | HPGD (0.38) | HPGDALDH1A1TSHRLMNAL3MBTL1 | |
| SCHEMBL7440274 | 0.81 | HPGD (0.33) | HPGDALDH1A1TSHRLMNA | |
| SCHEMBL7440268 | 0.81 | HPGD (0.33) | HPGDALDH1A1TSHRLMNA | |
| SCHEMBL7442942 | 0.80 | NPSR1 (0.39) | HPGDALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL7442946 | 0.80 | NPSR1 (0.39) | HPGDALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL7429720 | 0.80 | HPGD (0.32) | HPGDALDH1A1TSHRLMNANPSR1 | |
| SCHEMBL7429710 | 0.80 | HPGD (0.32) | HPGDALDH1A1TSHRLMNANPSR1 | |
| SCHEMBL7437499 | 0.79 | HPGD (0.41) | HPGDALDH1A1TSHRLMNAL3MBTL1 | |
| SCHEMBL7441294 | 0.79 | NPSR1 (0.39) | HPGDALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL7437284 | 0.77 | LMNA (0.33) | LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |