Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429710 | 1.00 | HPGD (0.32) | HPGDALDH1A1LMNATSHRGABRA1 | |
| SCHEMBL7440268 | 0.92 | HPGD (0.33) | HPGDALDH1A1LMNATSHR | |
| SCHEMBL7440274 | 0.92 | HPGD (0.33) | HPGDALDH1A1LMNATSHR | |
| SCHEMBL7442942 | 0.86 | NPSR1 (0.39) | HPGDALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL7442946 | 0.86 | NPSR1 (0.39) | HPGDALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL7441294 | 0.85 | NPSR1 (0.39) | HPGDALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL7437284 | 0.84 | LMNA (0.33) | LMNANPSR1 | |
| SCHEMBL7446073 | 0.80 | ALDH1A1 (0.33) | HPGDALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL7446066 | 0.80 | ALDH1A1 (0.33) | HPGDALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL7448893 | 0.80 | GABRA1 (0.48) | LMNAGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |