Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443767 | 0.93 | PTGER1 (0.51) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7447783 | 0.92 | PTGER1 (0.49) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7452183 | 0.91 | SMPD1 (0.54) | PTGER1TLR7 | |
| SCHEMBL7445338 | 0.90 | PTGER1 (0.50) | PTGER1TLR7 | |
| SCHEMBL7448062 | 0.90 | TLR7 (0.48) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7503159 | 0.89 | MAPT (0.51) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL6983082 | 0.88 | PTGER1 (0.56) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7447425 | 0.88 | NPC1 (0.52) | PTGER1TLR7TDP1 | |
| SCHEMBL7087561 | 0.88 | PTGER1 (0.52) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7607568 | 0.87 | PTGER1 (0.53) | PTGER1TLR7HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | claimed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |