Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443767 | 0.94 | PTGER1 (0.51) | PTGER1TLR7HDAC1HDAC3HDAC7 | |
| SCHEMBL7447138 | 0.92 | PTGER1 (0.54) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7503159 | 0.89 | MAPT (0.51) | PTGER1TLR7HDAC1HDAC3HDAC7 | |
| SCHEMBL7450591 | 0.89 | PTGER1 (0.51) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7452183 | 0.87 | SMPD1 (0.54) | PTGER1TLR7 | |
| SCHEMBL7448062 | 0.86 | TLR7 (0.48) | PTGER1TLR7HDAC1HDAC3HDAC7 | |
| SCHEMBL7447425 | 0.84 | NPC1 (0.52) | PTGER1TLR7 | |
| SCHEMBL7448607 | 0.84 | PTGER1 (0.46) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7450001 | 0.84 | SCD (0.53) | PTGER1TLR7HPGD | |
| SCHEMBL6983082 | 0.82 | PTGER1 (0.56) | PTGER1TLR7HDAC1HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | claimed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |