Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.74 |
| ▸ | PDE4A | P27815 | 4/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.74 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447179 | 1.00 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DABCG2 | |
| SCHEMBL7301103 | 0.87 | KDM4E (0.69) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL7301099 | 0.87 | KDM4E (0.69) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL30025682 | 0.87 | KDM4E (0.69) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL3133053 | 0.85 | ABCG2 (0.85) | PDE4BPDE4APDE4CPDE4DABCG2 | |
| SCHEMBL3133060 | 0.85 | ABCG2 (0.85) | PDE4BPDE4APDE4CPDE4DABCG2 | |
| SCHEMBL10365559 | 0.85 | ABCG2 (0.85) | PDE4BPDE4APDE4CPDE4DABCG2 | |
| SCHEMBL30384064 | 0.85 | ABCG2 (0.85) | PDE4BPDE4APDE4CPDE4DABCG2 | |
| SCHEMBL7357136 | 0.84 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL7929068 | 0.84 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |