SCHEMBL7447639

SCHEMBL7447639

CCCCCCCc1cc[c]cc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 3/20 0.46
TSHR P16473 2/20 0.46
TP53 P04637 2/20 0.46
CYP3A4 P08684 2/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
ALOX5 P09917 1/20 0.46
MAPT P10636 1/20 0.46
ALOX15 P16050 1/20 0.46
HTT P42858 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
LIPG Q9Y5X9 1/20 0.40
HTR2A P28223 1/20 0.39
CNR2 P34972 2/20 0.36
ESR1 P03372 2/20 0.35
ADRA2A P08913 2/20 0.35
ADORA3 P0DMS8 2/20 0.35
TACR2 P21452 2/20 0.35
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27298915 1.00 TYR (0.46) TYRTSHRTP53CYP3A4MEN1
SCHEMBL27297994 1.00 TYR (0.46) TYRTSHRTP53CYP3A4MEN1
SCHEMBL27327339 1.00 TYR (0.46) TYRTSHRTP53CYP3A4MEN1
SCHEMBL8038209 1.00 TYR (0.46) TYRTSHRTP53CYP3A4MEN1
SCHEMBL27305337 1.00 TYR (0.46) TYRTSHRTP53CYP3A4MEN1
SCHEMBL463162 0.98 TYR (0.43) TYRTSHRTP53CYP3A4MEN1
SCHEMBL7443632 0.93 TYR (0.43) TYRTSHRTP53CYP3A4MEN1
SCHEMBL4680155 0.85 PRKCI (0.31)
SCHEMBL28336992 0.84 TYR (0.40) TYRTSHRTP53CYP3A4MEN1
SCHEMBL4865770 0.83 LIPG (0.43) TYRTSHRTP53CYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165557-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2002-01-02 EP disclosed
WO-2000059905-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2000-10-12 WO disclosed
CN-1035107-A FLUORINATED OLIGOPHENYL DERIVATIVES MERCK PATENT GMBH (DE) 1989-08-30 CN disclosed