Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | FABP6 | P51161 | 1/20 | 0.49 |
| ▸ | DNM2 | P50570 | 4/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28020759 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL31066860 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL11124152 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL28020389 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL10606557 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL10607875 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL31066872 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL30205633 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL1573818 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT | |
| SCHEMBL28054301 | 1.00 | ALOX12 (0.60) | ALOX12CYP2C19CYP1A2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238153-A2 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| CN-108473484-A | Compounds useful as TRPM8 modulators | 赛诺米克斯公司 | 2018-08-31 | — | — | CN | disclosed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238153-A2 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIPK1, RIPK2, RIPK3 | ALOX12 2560/4885CYP2C19 4876/4885CYP1A2 4865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.