SCHEMBL7447859

SCHEMBL7447859

c1ccc(-c2ccc(Cc3ccncc3)s2)cc1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.54
CYP2A6 P11509 7/20 0.53
CYP2C19 P33261 6/20 0.53
CYP3A4 P08684 6/20 0.53
CYP2C9 P11712 5/20 0.53
CYP2E1 P05181 4/20 0.53
CYP2B6 P20813 4/20 0.53
CYP11B1 P15538 6/20 0.51
CYP11B2 P19099 6/20 0.51
CYP17A1 P05093 4/20 0.47
CYP2D6 P10635 5/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C8 P10632 1/20 0.46
NOTUM Q6P988 1/20 0.42
CYP19A1 P11511 2/20 0.41
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
TRPV1 Q8NER1 1/20 0.40
S1PR1 P21453 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5972875 0.87 CYP2A6 (0.62) PRKCICYP2A6CYP2C19CYP3A4CYP2C9
SCHEMBL27968356 0.83 CYP2A6 (0.64) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL4325292 0.79 TRPV1 (0.54) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL27968350 0.79 CYP2E1 (0.49) PRKCICYP2A6CYP2C19CYP3A4CYP2C9
SCHEMBL9199257 0.77 NOTUM (0.64) PRKCICYP2A6CYP2C19CYP3A4CYP2C9
SCHEMBL1692333 0.76 SMN1; SMN2 (0.49) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL4316965 0.76 APP (0.53) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL27968335 0.76 CYP2E1 (0.62) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL4310633 0.76 LTA4H (0.56) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1
SCHEMBL27968341 0.76 HSD17B1 (0.51) CYP2A6CYP2C19CYP3A4CYP2C9CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999043682-A9 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORP (US) 1999-11-11 WO claimed
WO-1999043682-A1 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORPORATION (US) 1999-09-02 WO claimed
WO-1999043682-A9 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORP (US) 1999-11-11 WO disclosed
WO-1999043682-A1 2-(HET-)ARYL-4-(CYCLIC AMINO SUBSTITUTED) HETEROARYL FUSED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS (ANT-)AGONISTS FOR GABA (A) BRAIN RECEPTORS NEUROGEN CORPORATION (US) 1999-09-02 WO disclosed