Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452320 | 0.83 | F2 (0.35) | NAMPTNPC1HSD17B10ALDH1A1CTSS | |
| SCHEMBL7447948 | 0.82 | NAMPT (0.40) | NAMPTNPC1PKMMAPK1HSD17B10 | |
| SCHEMBL6257637 | 0.81 | NAMPT (0.33) | NAMPTNPC1ALDH1A1CTSBLPAR1 | |
| SCHEMBL7486324 | 0.79 | FAAH (0.53) | NAMPTNPC1MAPK1RAB9A | |
| SCHEMBL6251138 | 0.78 | GRIK1 (0.38) | ADRB2LPAR1LPAR5 | |
| SCHEMBL6182144 | 0.78 | NAMPT (0.46) | NAMPTNPC1GAAALDH1A1MEN1 | |
| SCHEMBL6183130 | 0.77 | GAA (0.49) | NAMPTGAAMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL6183489 | 0.77 | NAMPT (0.46) | NAMPTNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL6255637 | 0.76 | LPAR1 (0.31) | ALDH1A1CTSBMEN1KMT2ALPAR1 | |
| SCHEMBL6252192 | 0.75 | SRD5A2 (0.47) | CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539192-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1161415-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | claimed |
| WO-2000055126-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | claimed |