Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.55 |
| ▸ | CTSL | P07711 | 13/20 | 0.55 |
| ▸ | CTSS | P25774 | 9/20 | 0.55 |
| ▸ | CTSB | P07858 | 5/20 | 0.55 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445945 | 0.86 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7449707 | 0.85 | CTSK (0.57) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453377 | 0.85 | CTSK (0.42) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453382 | 0.85 | TAS1R3 (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7449697 | 0.84 | CTSK (0.42) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7441241 | 0.79 | CTSK (0.53) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7508575 | 0.75 | CTSK (0.47) | CTSKCTSLCTSSCTSBKDM4E | |
| SCHEMBL7447956 | 0.75 | CTSK (0.72) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7445941 | 0.73 | CTSK (0.96) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7450638 | 0.73 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140897-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1140897-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039115-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |