Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447138 | 0.87 | PTGER1 (0.54) | PTGER1TLR7RXRARXRBRXRG | |
| SCHEMBL7448190 | 0.86 | PTGER1 (0.42) | PTGER1TLR7MEN1GAAKMT2A | |
| SCHEMBL7443767 | 0.85 | PTGER1 (0.51) | PTGER1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL7447783 | 0.84 | PTGER1 (0.49) | PTGER1TLR7RXRARXRBRXRG | |
| SCHEMBL7448062 | 0.82 | TLR7 (0.48) | PTGER1TLR7RXRARXRBRXRG | |
| SCHEMBL7503159 | 0.81 | MAPT (0.51) | PTGER1TLR7SCDHDAC1HDAC8 | |
| SCHEMBL7450001 | 0.80 | SCD (0.53) | PTGER1TLR7SCDHPGDMEN1 | |
| SCHEMBL7452183 | 0.79 | SMPD1 (0.54) | PTGER1TLR7MEN1KMT2A | |
| SCHEMBL6983082 | 0.79 | PTGER1 (0.56) | PTGER1TLR7CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7087561 | 0.78 | PTGER1 (0.52) | PTGER1TLR7HPGDHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | claimed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |