SCHEMBL7448667

SCHEMBL7448667

COc1ccccc1C(c1ccccc1OC)c1cccc(OC)c1O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.57
KDM4E B2RXH2 4/20 0.57
TP53 P04637 2/20 0.57
HPGD P15428 2/20 0.57
ALOX15 P16050 2/20 0.57
HSD17B10 Q99714 2/20 0.57
ALDH1A1 P00352 2/20 0.57
MAPK1 P28482 2/20 0.57
LMNA P02545 1/20 0.57
CYP3A4 P08684 1/20 0.57
ALOX12 P18054 1/20 0.57
CYP2C19 P33261 2/20 0.54
CYP2D6 P10635 1/20 0.54
CYP1A2 P05177 1/20 0.51
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
TSHR P16473 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TLR2 O60603 1/20 0.47
ERN1 O75460 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL592169 0.87 MAPT (0.52) MAPTKDM4ETP53HPGDALOX15
SCHEMBL2066662 0.85 CA1 (0.63) MAPTKDM4ETP53HPGDALOX15
SCHEMBL5583967 0.82 CA1 (0.61) MAPTKDM4ETP53HPGDALOX15
SCHEMBL8162266 0.82 KDM4E (0.59) MAPTKDM4ETP53HPGDALOX15
SCHEMBL2737304 0.82 HPGD (0.64) MAPTKDM4ETP53HPGDALOX15
SCHEMBL30375446 0.80 MAPT (0.49) MAPTKDM4ETP53HPGDALOX15
SCHEMBL278351 0.80 MAPT (0.49) MAPTKDM4ETP53HPGDALOX15
SCHEMBL10815297 0.80 KDM4E (0.57) MAPTKDM4ETP53HPGDALOX15
SCHEMBL2200629 0.79 MAPT (0.47) MAPTKDM4ETP53HPGDALOX15
SCHEMBL31409236 0.79 MAPT (0.47) MAPTKDM4ETP53HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051169-A4 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES VIROPHARMA INC (US) 2002-05-29 EP disclosed
EP-1051169-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES Viropharma Incorporated (US) 2000-11-15 EP disclosed
WO-1999038508-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES VIROPHARMA INCORPORATED (US) 1999-08-05 WO disclosed