Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177760 | 0.87 | HTR2B (0.52) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL6178657 | 0.86 | HTR2B (0.57) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL9199296 | 0.85 | HTR2B (0.56) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL6174221 | 0.81 | HTR2B (0.49) | HTR2BPGAM1HTR3AHTR2CMAPT | |
| SCHEMBL6176274 | 0.81 | IDH1 (0.49) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL9196012 | 0.81 | HTR2B (0.46) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL6173771 | 0.79 | CNR1 (0.50) | HTR2BHTR2CMAPT | |
| SCHEMBL9199124 | 0.78 | IGF1R (0.46) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL9195193 | 0.77 | HTR2B (0.45) | HTR2BDAOPGAM1HTR3AHTR2C | |
| SCHEMBL6174060 | 0.77 | HTR2B (0.44) | HTR2BDAOPGAM1HTR3AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |