Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502098 | 0.78 | EPHX1 (0.57) | EPHX1POLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL255421 | 0.76 | EPHX1 (0.59) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL11007528 | 0.75 | EPHX1 (0.53) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL4078143 | 0.75 | ARG1 (0.47) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL12789535 | 0.74 | EPHX1 (0.60) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL28895020 | 0.74 | EPHX1 (0.57) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL14342617 | 0.74 | EPHX1 (0.44) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL1802727 | 0.73 | EPHX1 (0.55) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL18745320 | 0.72 | EPHX1 (0.50) | EPHX1POLBSIGMAR1GNAI3GNAO1 | |
| SCHEMBL2324691 | 0.72 | EPHX1 (0.62) | EPHX1POLBSIGMAR1GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706525-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | Novartis AG (CH) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001353-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | CIBA-GEIGY AG (CH) | 1995-01-12 | — | — | WO | disclosed |