Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 5/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21798820 | 0.87 | HTT (0.57) | KDM4EACHEHTTNCOA1NCOA3 | |
| SCHEMBL7027773 | 0.81 | HTT (0.51) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL5889352 | 0.81 | HTT (0.51) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL8063041 | 0.81 | HTT (0.51) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL8075935 | 0.77 | RAB9A (0.39) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL8075930 | 0.77 | RAB9A (0.39) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL8070827 | 0.74 | HTT (0.51) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL7248408 | 0.74 | KDM4E (0.49) | KDM4EACHEHTTNCOA1NCOA3 | |
| SCHEMBL8070825 | 0.74 | HTT (0.51) | KDM4EHTTNCOA1NCOA3LMNA | |
| SCHEMBL7568637 | 0.74 | KDM4E (0.49) | KDM4EACHEHTTNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000609-A2 | 2,6,7-SUBSTITUTED TETRALINES USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-01-03 | — | — | WO | claimed |
| WO-2002000609-A2 | 2,6,7-SUBSTITUTED TETRALINES USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-01-03 | — | — | WO | disclosed |