Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.60 |
| ▸ | MMP13 | P45452 | 4/20 | 0.60 |
| ▸ | MMP3 | P08254 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111262 | 1.00 | MMP1 (0.60) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL5756389 | 0.91 | MMP1 (0.71) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL7105952 | 0.91 | MMP1 (0.71) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL5759603 | 0.90 | MMP1 (0.54) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL7507399 | 0.90 | MMP1 (0.54) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL8576750 | 0.87 | MMP1 (0.56) | MMP1ADAM17MMP13MMP3MMP8 | |
| SCHEMBL5757107 | 0.86 | ADAM17 (0.51) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL5756594 | 0.81 | MMP1 (0.72) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL5758290 | 0.80 | MMP1 (0.69) | MMP1ADAM17MMP13MMP3MMP9 | |
| SCHEMBL27573429 | 0.80 | ADAM17 (0.59) | MMP1ADAM17MMP13MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |