Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554194 | 1.00 | KMT2A (0.48) | KMT2AMEN1ANPEPERAP2DPP7 | |
| SCHEMBL25344962 | 0.97 | MEN1 (0.44) | KMT2AMEN1ANPEPERAP2DPP7 | |
| SCHEMBL8130430 | 0.76 | MEN1 (0.55) | KMT2AMEN1ANPEPERAP2MAPT | |
| SCHEMBL1674470 | 0.76 | MEN1 (0.55) | KMT2AMEN1ANPEPERAP2MAPT | |
| SCHEMBL7539239 | 0.74 | DPP7 (0.48) | ANPEPERAP2DPP7CYP2D6CYP2C19 | |
| SCHEMBL4209395 | 0.73 | — | — | |
| SCHEMBL18205131 | 0.72 | MEN1 (0.50) | KMT2AMEN1ANPEPERAP2MAPT | |
| SCHEMBL358919 | 0.72 | MEN1 (0.50) | KMT2AMEN1ANPEPERAP2MAPT | |
| SCHEMBL6783279 | 0.72 | MEN1 (0.50) | KMT2AMEN1ANPEPERAP2MAPT | |
| SCHEMBL11590989 | 0.72 | MEN1 (0.64) | KMT2AMEN1ANPEPERAP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030845-B1 | HETEROCYCLIC COMPOUNDS HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2002-04-10 | — | — | EP | disclosed |
| EP-1030845-A1 | HETEROCYCLIC COMPOUNDS HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| US-6063786-A | Heterocyclic compounds having MMP and TNF inhibitory activity | DARWIN DISCOVERY, LTD. (GB) | 2000-05-16 | — | — | US | disclosed |
| WO-1999024408-A1 | HETEROCYCLIC COMPOUNDS HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |