Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447516 | 0.90 | SIRT2 (0.60) | APEX1SIRT2SMN1; SMN2LMNAHTT | |
| SCHEMBL7454070 | 0.84 | APEX1 (0.59) | APEX1SIRT2SMN1; SMN2LMNAHTT | |
| SCHEMBL7458372 | 0.84 | APEX1 (0.61) | APEX1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL15821036 | 0.82 | SIRT2 (0.60) | SIRT2SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL6357252 | 0.81 | SIRT2 (0.65) | SIRT2SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL7453897 | 0.79 | APEX1 (0.66) | APEX1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL15953150 | 0.79 | SIRT2 (0.80) | SIRT2SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL15838843 | 0.78 | SIRT2 (0.78) | SIRT2LMNAMAPTALDH1A1 | |
| SCHEMBL15838799 | 0.78 | SIRT2 (0.64) | SIRT2SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL6353746 | 0.78 | SIRT2 (0.61) | SIRT2SMN1; SMN2LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001098274-A2 | SULPHONAMIDE DERIVATIVES | CELLTECH CHIROSCIENCE LIMITED (GB) | 2001-12-27 | — | — | WO | claimed |
| WO-2001098274-A2 | SULPHONAMIDE DERIVATIVES | CELLTECH CHIROSCIENCE LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |