Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449698 | 0.90 | APEX1 (0.66) | SIRT2MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7453072 | 0.85 | GAA (0.54) | SIRT2TSHRGAANPSR1MAPT | |
| SCHEMBL7454168 | 0.82 | ALDH1A1 (0.64) | SIRT2TSHRGAANPSR1MAPT | |
| SCHEMBL7452186 | 0.80 | APEX1 (0.53) | TSHRGAANPSR1MAPTLMNA | |
| SCHEMBL7452639 | 0.79 | RXFP1 (0.55) | TSHRGAANPSR1CYP1A2CYP2D6 | |
| SCHEMBL7450794 | 0.78 | TSHR (0.57) | TSHRGAANPSR1CYP1A2CYP2D6 | |
| SCHEMBL7453515 | 0.78 | APEX1 (0.57) | TSHRGAANPSR1MAPTLMNA | |
| SCHEMBL7447506 | 0.77 | CYP1A2 (0.56) | TSHRCYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL15953150 | 0.77 | SIRT2 (0.80) | SIRT2MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL15838843 | 0.77 | SIRT2 (0.78) | SIRT2MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001098274-A2 | SULPHONAMIDE DERIVATIVES | CELLTECH CHIROSCIENCE LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |