Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.64 |
| ▸ | PDE4A | P27815 | 9/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074189 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3160402 | 0.80 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8569873 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL26921125 | 0.77 | OPRM1 (0.47) | — | |
| SCHEMBL29839094 | 0.77 | OPRM1 (0.47) | — | |
| SCHEMBL7445703 | 0.77 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL192143 | 0.76 | KMT2A (0.47) | — | |
| SCHEMBL1388173 | 0.75 | PDE4B (0.84) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3546352 | 0.74 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL17390155 | 0.74 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |