Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21869793 | 0.95 | POLB (0.58) | KDM4EALDH1A1SPHK2POLBSPHK1 | |
| SCHEMBL7625352 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1POLBHRH3TSHR | |
| SCHEMBL9650151 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1SPHK2POLBHRH3 | |
| SCHEMBL21409037 | 0.84 | SMN1; SMN2 (0.56) | KDM4ESPHK2HRH3OPRM1OPRK1 | |
| SCHEMBL10349406 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1HRH3OPRM1OPRK1 | |
| SCHEMBL2274909 | 0.84 | POLB (0.61) | KDM4EALDH1A1POLBSPHK1MEN1 | |
| SCHEMBL2274911 | 0.84 | POLB (0.61) | KDM4EALDH1A1POLBSPHK1MEN1 | |
| SCHEMBL28957118 | 0.82 | FKBP1A (0.58) | ALDH1A1FKBP1A | |
| SCHEMBL7458698 | 0.81 | MCHR1 (0.53) | KDM4EALDH1A1POLBHRH3 | |
| SCHEMBL6228519 | 0.80 | CYP3A4 (0.55) | KDM4EOPRM1OPRK1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137412-A4 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1137412-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033788-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES INC. (US) | 2000-06-15 | — | — | WO | disclosed |