Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451913 | 0.91 | GABRP (0.47) | GRM2NPC1RAB9ASMN1; SMN2GABRA5 | |
| SCHEMBL28341249 | 0.86 | GRM2 (0.45) | GRM2PPIANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4190714 | 0.80 | KDM4E (0.50) | NPC1RAB9ASMN1; SMN2GABRA5ALDH1A1 | |
| SCHEMBL26006080 | 0.79 | NPC1 (0.40) | GRM2NPC1RAB9ASMN1; SMN2HTR1A | |
| SCHEMBL10203014 | 0.79 | PPIA (0.39) | GRM2PPIAGABRA5GABRPGABRD | |
| SCHEMBL6803 | 0.79 | CYP2C19 (0.56) | NPC1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL29379587 | 0.79 | CYP2C19 (0.56) | NPC1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL370672 | 0.79 | NPC1 (0.44) | GRM2NPC1RAB9ASMN1; SMN2GABRA5 | |
| SCHEMBL29582472 | 0.79 | NPC1 (0.44) | GRM2NPC1RAB9ASMN1; SMN2GABRA5 | |
| SCHEMBL16511359 | 0.78 | TSHR (0.43) | GRM2NPC1RAB9ASMN1; SMN2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |