Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438660 | 0.87 | ALDH1A1 (0.31) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7445565 | 0.86 | ALDH1A1 (0.31) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7443467 | 0.85 | MAPT (0.33) | MAPTLMNATP53ALDH1A1HPGD | |
| SCHEMBL7443227 | 0.85 | LMNA (0.33) | MAPTLMNATP53ALDH1A1KMT2A | |
| SCHEMBL7439791 | 0.84 | ALDH1A1 (0.31) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7446404 | 0.84 | TP53 (0.33) | MAPTTP53ALDH1A1HPGDKMT2A | |
| SCHEMBL7443868 | 0.83 | ALDH1A1 (0.31) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7441119 | 0.83 | ALDH1A1 (0.35) | MAPTTP53ALDH1A1HPGDKMT2A | |
| SCHEMBL9199590 | 0.82 | MAPT (0.33) | MAPTLMNATP53ALDH1A1HPGD | |
| SCHEMBL7445467 | 0.82 | ALDH1A1 (0.30) | ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | claimed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | claimed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |