SCHEMBL7450338

SCHEMBL7450338

O=C(NCc1ccccc1)C1CCCCN1Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CACNA1G O43497 1/20 0.60
PTGER4 P35408 2/20 0.59
FKBP1A P62942 4/20 0.58
NPSR1 Q6W5P4 1/20 0.56
HDAC1 Q13547 2/20 0.56
HDAC2 Q92769 2/20 0.56
HDAC3 O15379 1/20 0.56
CNR2 P34972 1/20 0.55
ALDH1A1 P00352 3/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2C9 P11712 1/20 0.55
PKM P14618 1/20 0.55
CYP2C19 P33261 1/20 0.55
USP2 O75604 1/20 0.55
HPGD P15428 1/20 0.55
POLB P06746 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.54
OPRL1 P41146 1/20 0.53
F2 P00734 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2441194 0.96 FKBP1A (0.60) CACNA1GFKBP1ANPSR1HDAC1HDAC2
SCHEMBL7452551 0.96 FKBP1A (0.60) CACNA1GFKBP1ANPSR1HDAC1HDAC2
SCHEMBL8544795 0.84 FKBP1A (0.59) PTGER4FKBP1ANPSR1ALDH1A1CYP3A4
SCHEMBL5716987 0.84 CACNA1G (0.55) CACNA1GNPSR1CNR2ALDH1A1OPRL1
SCHEMBL5154461 0.83 F2 (0.56) PTGER4FKBP1AALDH1A1CYP3A4CYP2C9
SCHEMBL5157785 0.83 F2 (0.56) PTGER4FKBP1AALDH1A1CYP3A4CYP2C9
SCHEMBL3713829 0.83 SMN1; SMN2 (0.63) CACNA1GNPSR1CNR2CYP2C19SMN1; SMN2
SCHEMBL3713831 0.83 SMN1; SMN2 (0.63) CACNA1GNPSR1CNR2CYP2C19SMN1; SMN2
SCHEMBL16714062 0.83 SMN1; SMN2 (0.63) CACNA1GNPSR1CNR2CYP2C19SMN1; SMN2
SCHEMBL21696782 0.82 FKBP1A (0.61) PTGER4FKBP1ANPSR1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1137412-A4 SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF AMERICAN BIOGENETIC SCIENCES (US) 2002-04-03 EP disclosed
EP-1137412-A2 SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF AMERICAN BIOGENETIC SCIENCES, INC. (US) 2001-10-04 EP disclosed
WO-2000033788-A2 SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF AMERICAN BIOGENETIC SCIENCES INC. (US) 2000-06-15 WO disclosed