Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.43 |
| ▸ | DRD3 | P35462 | 14/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457880 | 0.86 | NAMPT (0.42) | DRD2DRD3FYN | |
| SCHEMBL7404035 | 0.82 | FYN (0.49) | DRD2DRD3DRD4FYN | |
| SCHEMBL7405367 | 0.80 | MEN1 (0.42) | DRD2DRD3FYN | |
| SCHEMBL7408334 | 0.77 | DRD3 (0.61) | DRD2DRD3DRD4 | |
| SCHEMBL7408331 | 0.77 | DRD3 (0.61) | DRD2DRD3DRD4 | |
| SCHEMBL7403573 | 0.75 | DRD3 (0.67) | DRD2DRD3DRD4 | |
| SCHEMBL7403568 | 0.75 | DRD3 (0.67) | DRD2DRD3DRD4 | |
| SCHEMBL7405701 | 0.74 | IDO1 (0.44) | FYN | |
| SCHEMBL7401141 | 0.71 | FYN (0.54) | DRD2DRD3DRD4FYN | |
| SCHEMBL7408566 | 0.70 | FYN (0.48) | DRD2DRD3DRD4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |