Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861350 | 0.85 | CYP19A1 (0.44) | DRD3DRD2CYP19A1TSHRNPSR1 | |
| SCHEMBL7854688 | 0.82 | TBXA2R (0.54) | DRD3DRD2CYP19A1TBXA2R | |
| SCHEMBL7450377 | 0.80 | DRD2 (0.43) | DRD3DRD2FYN | |
| SCHEMBL7457880 | 0.78 | NAMPT (0.42) | MEN1KMT2ADRD3DRD2FYN | |
| SCHEMBL7408257 | 0.78 | DRD3 (0.39) | DRD3DRD2FYN | |
| SCHEMBL7457371 | 0.77 | DRD3 (0.61) | MEN1KMT2ADRD3DRD2TBXA2R | |
| SCHEMBL7457363 | 0.77 | DRD3 (0.61) | MEN1KMT2ADRD3DRD2TBXA2R | |
| SCHEMBL8502463 | 0.75 | DRD3 (0.50) | DRD3DRD2CYP19A1TDP1 | |
| SCHEMBL7411290 | 0.75 | DRD3 (0.67) | DRD3DRD2TBXA2R | |
| SCHEMBL7411286 | 0.75 | DRD3 (0.67) | DRD3DRD2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |